Jaap W Groothoff Selected Research

Nephrocalcinosis

3/2022	Randomized Clinical Trial on the Long-Term Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1.
2/2022	Long-Term Transplantation Outcomes in Patients With Primary Hyperoxaluria Type 1 Included in the European Hyperoxaluria Consortium (OxalEurope) Registry.
1/2021	Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1: A Placebo-Controlled Randomized Clinical Trial.
1/2021	Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
1/2020	Development and Validation of a New Gas Chromatography-Tandem Mass Spectrometry Method for the Measurement of Enrichment of Glyoxylate Metabolism Analytes in Hyperoxaluria Patients Using a Stable Isotope Procedure.
12/2019	Patients with primary hyperoxaluria type 2 have significant morbidity and require careful follow-up.
11/2011	Efficacy and safety of Oxalobacter formigenes to reduce urinary oxalate in primary hyperoxaluria.
8/2006	High incidence of hyperoxaluria in generalized peroxisomal disorders.
2/2003	Primary hyperoxaluria type 1 in The Netherlands: prevalence and outcome.

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Jaap W Groothoff Research Topics

Disease

23	Chronic Kidney Failure (Chronic Renal Failure) 11/2019 - 10/2004
15	Renal Insufficiency (Renal Failure) 07/2022 - 02/2003
10	Hyperoxaluria (Oxaluria) 07/2022 - 02/2003
9	Primary hyperoxaluria type 1 07/2022 - 08/2004
9	Nephrocalcinosis 03/2022 - 02/2003
8	Hypertension (High Blood Pressure) 12/2017 - 02/2002
6	Kidney Calculi (Kidney Stone) 03/2022 - 11/2011
5	Inborn Genetic Diseases (Disease, Hereditary) 07/2022 - 11/2011
5	Primary Hyperoxaluria (Oxaluria, Primary) 01/2022 - 11/2011
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 03/2005
5	Infections 08/2016 - 02/2002
4	Homozygous Familial Hypercholesterolemia 01/2021 - 01/2019
3	Injection Site Reaction 07/2022 - 01/2021
3	Rare Diseases (Rare Disease) 01/2021 - 10/2015
3	Neoplasms (Cancer) 01/2018 - 06/2015
3	Atypical Hemolytic Uremic Syndrome 02/2006 - 10/2004
2	Kidney Diseases (Kidney Disease) 07/2022 - 05/2017
2	Chronic Renal Insufficiency 12/2019 - 12/2014
2	Vasculitis (Vasculitides) 01/2019 - 10/2018
2	Hemolytic-Uremic Syndrome 10/2018 - 10/2004
2	Overweight 12/2017 - 11/2013
2	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2016 - 10/2015
1	Primary hyperoxaluria type 2 12/2019
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 10/2019
1	Glomerulonephritis 01/2019
1	Xanthomatosis (Xanthoma) 01/2019
1	Arteriovenous Fistula 01/2019
1	Prune Belly Syndrome 01/2018
1	Carcinoma (Carcinomatosis) 01/2018
1	Cakut 05/2017
1	Body Weight (Weight, Body) 05/2017
1	Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I) 11/2016
1	Anemia 11/2016
1	Liver Cirrhosis (Hepatic Cirrhosis) 11/2016
1	Liver Diseases (Liver Disease) 11/2016
1	Virus Diseases (Viral Diseases) 08/2016
1	Urinary Tract Infections (Urinary Tract Infection) 02/2016
1	Proteinuria 10/2015
1	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 10/2015
1	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 06/2015
1	Hyperphosphatemia 05/2015
1	Hyperparathyroidism 05/2015
1	Hypercalcemia (Milk Alkali Syndrome) 05/2015
1	Hypophosphatemia 05/2015
1	Hypocalcemia 05/2015
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 05/2015
1	Autosomal Dominant Polycystic Kidney (ADPKD) 12/2014
1	Pediatric Obesity 11/2013

Drug/Important Bio-Agent (IBA)

10	OxalatesIBA 07/2022 - 08/2006
9	Edetic Acid (EDTA)FDA Link 01/2018 - 11/2011
6	CreatinineIBA 07/2022 - 10/2004
5	glyoxylic acid (glyoxylate)IBA 01/2022 - 08/2004
4	lumasiranIBA 07/2022 - 01/2021
4	oxidized low density lipoproteinIBA 01/2021 - 01/2019
3	LDL CholesterolIBA 01/2021 - 01/2019
3	Lipoproteins (Lipoprotein)IBA 01/2020 - 01/2019
3	Antihypertensive Agents (Antihypertensives)IBA 11/2016 - 11/2011
2	CholesterolIBA 01/2021 - 01/2019
2	LipidsIBA 01/2021 - 03/2014
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021 - 10/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 10/2019
2	CalciumIBA 05/2015 - 04/2009
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/2004 - 02/2002
1	EnzymesIBA 02/2022
1	nedosiranIBA 01/2022
1	Ezetimibe (Zetia)FDA Link 01/2021
1	evinacumabIBA 01/2021
1	Calcium OxalateIBA 01/2020
1	IsotopesIBA 01/2020
1	Pravastatin (Pravachol)FDA LinkGeneric 10/2019
1	Hemoglobins (Hemoglobin)IBA 01/2019
1	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2017
1	Oxidoreductases (Dehydrogenase)IBA 12/2017
1	Cortisone FDA Link 12/2017
1	SodiumIBA 02/2017
1	AldosteroneIBA 02/2017
1	PotassiumIBA 02/2017
1	ReninIBA 02/2017
1	Succimer (Dimercaptosuccinic Acid)FDA Link 02/2017
1	Antiviral Agents (Antivirals)IBA 08/2016
1	eculizumab FDA Link 10/2015
1	Proteins (Proteins, Gene)FDA Link 10/2015
1	Dichlorodiphenyldichloroethane (DDD)IBA 10/2015
1	Rituximab (Mabthera)FDA Link 06/2015
1	Phosphorus (Red Phosphorus)IBA 05/2015
1	MineralsIBA 05/2015
1	Indicators and Reagents (Reagents)IBA 12/2014
1	Mupirocin (Bactroban)FDA LinkGeneric 12/2013
1	GlucocorticoidsIBA 11/2013

Therapy/Procedure

15	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2018 - 08/2005
11	Transplantation 02/2022 - 02/2002
9	Kidney Transplantation 05/2022 - 01/2005
9	Therapeutics 01/2021 - 10/2013
5	Renal Dialysis (Hemodialysis) 07/2022 - 11/2011
4	Blood Component Removal (Apheresis) 01/2021 - 01/2019
4	Peritoneal Dialysis 05/2017 - 03/2003
2	Liver Transplantation 12/2019 - 11/2016
2	Plasma Exchange 01/2005 - 10/2004
1	RNAi Therapeutics 01/2021
1	Central Venous Catheters 01/2019